I have had IBS for almost 15 years. Just in the last year things started to change. I had pain in the upper right side, under the rib cage. After several tests, it showed to be a grossly malfunctioning gallbladder. We took it out. Since the surgery I have not experienced the pain on the right side, but must eat a very restrictive diet. If I have a fatty meal, fried, dairy, oily foods, I have lower abdominal cramping, and diarrhea. I have been on questran, prevacid, and start started taking lotronex, a new IBS drug. So far still having attacks . If anyone has any suggestions, Please reply. Thank you leslie