I have had heart burn and acid reflux for years. I was eventually diagnosed with GERD. About a year later after being diagnosed with it I had to have my GB removed and my heart burn and acid reflux has gotten 10 times worse since then. They both tend to be worse at night. I am currently taking Prilosec 40 mg and zantac 300mg night. I take one 20mg prilosec twice a day. They seem to help me quite a bit but if I forget to take them I will definitely pay the price later that day or at night when I am trying to sleep.