In summary, this study demonstrates that treatment with bile acids has a detrimental effect on gallbladder emptying and also on filling in gallstone patients, particularly those who fail to eventually dissolve their stones. No differences in this action were observed between UDCA and CDCA. Upon gallstone dissolution, gallbladder contractility improves and is further enhanced after discontinuing the bile acids. Cholescintigraphy was of no value in predicting the outcome of such medical therapy.
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