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Bile acid secretion and biliary bile acid composition altered by cholecystectomy

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Bile acid secretion and biliary bile acid composition altered by cholecystectomy

  • Authors
  • Authors and affiliations
  • Juan R. Malagelada
  • Vay Liang W. Go
  • William H. J. Summerskill
  • Willard S. Gamble

Abstract

After cholecystectomy, bile secretion is continuous and 24-hour bile acid output exceeds that in health. Cholecystokinin-pancreozymin (CCK-PZ) influences neither bile acid secretion nor the bile acid composition of bile after the operation. It is proposed that the absence of the gallbladder causes more rapid enterohepatic recycling of bile acids and therefore increased bile acid secretion. The bile acid composition of bile following cholecystectomy is abnormal for the same reasons. A high proportion of secondary bile acids is present, including several found to be keto bile acids, and this is attributed to increased exposure of the bile acid pool to degradation by intestinal microorganisms.

Keywords

Public Health Acid Composition Bile Acid Acid Secretion Acid Output 

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Medical Department Harper & Row, Publishers, Inc. 1973
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